ABSTRACT
To assess the frequency of elevated LH/FSH ratio>l in women with polycystic ovary syndrome among local population. Cross-sectional study. This cross sectional study was carried out at two tertiary care hospitals in Karachi during October 2010 to Feb 2011. A total of 163 PCOS women of reproductive age [18-40years] fulfilling revised Rotterdam 2003 criteria were studied. The data recorded on a prescribed proforma include current age, age at menarche, menstrual irregularities, presence of hirsuitism, acne, infertility, familial nature, blood pressure, BMI, waist to hip ratio. Blood sample for gonadotropin assay were taken in random state on specific dates of menstrual cycle [day 6[th] to day 30[th]] in gel tube. Hormonal assay were performed using chemiluminescent immunoassay. Mean age of presentation of PCOS subjects was 24.88 +/- 5.35 years. Menstrual irregularities [99%] were the commonest presentation followed by acne [88%], hirsuitism [71%] and infertility [62%]. A high frequency [>71%] of elevated LH/FSH >1 ratio was observed among local population. The present study concludes that elevated LH/FSH ratio>l is a characteristic finding of Pakistani population of PCOS [present in = 71% of patients] and with proper sampling dates can be used as diagnostic tool for establishing the diagnosis of PCOS